With low ISO you have to use a wider aperture and/or longer exposure so there is more risk that your photo is unsharp or that the depth of field that is too shallow. There should be no noise.

For landscapes I do the same as on medium-format film - native ISO with small aperture, slow shutter speed and camera on a heavy tripod.

NOTE: I misunderstood the post. I thought he was talking about the native ISO of the sensor. I've never used the "Lo" settings